Cell line development
Our substantial experience in protein expression has lead to the development and optimisation of specific and original strains, culture media and vectors, which are particularly interesting in terms of several criteria, such as productivity of the process or GMP compliance.
We can propose high-producing and free-to-operate or proprietary expression systems to our clients in order for them to select the most suitable system for the drug candidate.
Microbial cell line development:
Highly efficient expression system
High expressing vectors for cytoplasmic, perisplasmic or secreted expression
Wide range of cell lines such as E. coli, Pichia pastoris, Yarrowia lipolytica, Saccharomyces cerevisiae, etc.
Selection of stable expression system
Mammalian cell line development:
Highly efficient expression systems
Serum-free and suspension-adapted cell lines
Clone selection process
Selection of genetic and phenotypic stable clones
Full traceability of all the steps and history of the selected clone with the support of the Quality Assurance team
In accordance with the project scope: therapeutic, diagnostic, etc.
Animal-free raw materials from the molecular biology to the production of Initial Cell Bank